THE HISTORICAL COLLECTION
First published Oct 27, 2024–Oct 26, 2026. Collected retrospectively, with original source dates preserved.
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Historical collection
This trial randomized 1,000 adults presenting to EDs with septic shock to restricted fluids with earlier vasopressors or more fluids with later vasopressors. Among 963 patients in the intention-to-treat population, median days alive and out of hospital at day 90 were 76 in both groups.
Historical collection
In this double-blind trial at 21 Danish hospitals, routine IV sodium bicarbonate did not improve sustained ROSC after in-hospital cardiac arrest. Of 913 randomized patients, 779 were eligible for the primary analysis.
Historical collection
This trial enrolled 1,840 ventilated adults who remained unresponsive after cardiac arrest. Conservative oxygen did not improve favorable functional survival at 180 days compared with a liberal strategy.
Historical collection
In this pragmatic trial at 47 EDs, balanced fluid and saline produced similar major adverse kidney event rates in children treated for suspected septic shock. Of 9,041 enrolled, 8,482 remained for analysis after withdrawal without permission to use data.
Historical collection
The adult update provides 129 statements, including 46 new statements. For ED care, it retains rapid antibiotics for shock or probable/definite sepsis, permits rapid investigation for possible sepsis without shock, and frames initial fluids as a conditional recommendation requiring repeated reassessment.
Historical collection
The pediatric update provides 61 statements, but only three recommendations have high- or moderate-certainty evidence. In settings with intensive care availability, it conditionally suggests up to 40–60 mL/kg during the first hour, using repeated small boluses and reassessment.
Historical collection
Across ten English air ambulance services, prehospital whole blood did not reduce death or massive transfusion within 24 hours compared with red cells and plasma. Of 942 randomized patients, 616 were analyzed after exclusions including nontraumatic hemorrhage and traumatic cardiac arrest.
Historical collection
The first AHA/ACC multisociety acute PE guideline introduces categories A–E to connect severity with outpatient care, admission and advanced therapy. It emphasizes prompt anticoagulation and prefers DOACs over vitamin K antagonists when appropriate.
Historical collection
This multicenter trial assigned 2,365 critically ill adults undergoing intubation to ketamine or etomidate. In-hospital mortality by day 28 was similar, while cardiovascular collapse during intubation occurred more often with ketamine.
Historical collection
In 1,467 analyzed patients with early septic shock, a personalized protocol targeting capillary refill normalization improved a hierarchical composite of death, duration of vital support, and hospital stay versus usual care. The difference was driven mainly by shorter vital support, rather than demonstrated mortality reduction.
Historical collection
The 2025 adult ALS guideline recommends attempting IV access first during adult cardiac arrest; IO is reasonable when IV access fails or is infeasible. Head-up CPR is not recommended outside clinical trials. POCUS for reversible causes or prognostication remains insufficiently established.
Historical collection
IDSA suggests shorter treatment for improving cUTI: 5–7 days of an effective fluoroquinolone or 7 days of another effective antibiotic. It also supports IV-to-oral transition when patients improve, tolerate oral medication and have an active oral option. Duration starts on the first effective treatment day.