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HISTORICAL SAMPLE ISSUE

Emergency Medicine Literature BriefJune 17, 2024

Coverage: Jun 10, 2024 through Jun 16, 2024 · America/Los_Angeles

Historical sample issue: a focused look at preoxygenation evidence. This demonstrates the brief format and is not a current weekly literature review.

AT A GLANCE

Clinical Takeaways

  • Airway: PREOXI found less peri-intubation hypoxemia with NIV than an oxygen mask in critically ill adults. Consider patient suitability when applying this regimen.

Practice-Changing / High Priority

Noninvasive Ventilation for Preoxygenation during Emergency Intubation

New England Journal of Medicine - Jun 13, 2024

Summary

PREOXI randomized 1,301 critically ill adults to NIV or an oxygen mask before intubation. Hypoxemia (SpO2 <85%) occurred in 9.1% versus 18.5% (absolute difference -9.4 percentage points; 95% CI -13.2 to -5.6).

Why it matters

Supports choosing NIV for preoxygenation in suitable critically ill adults to reduce peri-intubation hypoxemia. This studied regimen does not establish a survival benefit.

Limitations

Unblinded trial in US EDs and ICUs. Applicability depends on patient suitability for NIV; infrequent safety events do not establish equivalence.

Source: 10.1056/NEJMoa2313680

Full text: Open-access full text available

Abstract-based summary; methods text also checked for design. Open-access full text available for further appraisal. AI-generated · Not yet human-reviewed.

View study details

Publication notes

Published on EM Weekly Oct 26, 2026. Selection prioritizes potential ED impact and methodological strength. Automated ranking is an editorial aid, not a definitive judgment of clinical importance.

AI-generated · Not yet human-reviewed · Read the primary source and apply clinical judgment.